The continued engagement of multilateral agencies and institutions, providing technical assistance at country level, is vital for the effectiveness of global financing mechanisms, like the Global Fund. Without this in-country presence, and the accompanying capacity for rapid response, diagnostics and financing support—value for money and high-quality results cannot be guaranteed. This is more important than ever as the Global Fund moves to its new funding model, which more closely aligns international financing with national plans, timeframes and budgets, but increases technical assistance demands.