Scientific evidence and evidence-based action are essential to advance the Joint United Nations Programme on HIV/AIDS (UNAIDS) vision of zero HIV infections, zero discrimination and zero AIDS-related deaths. In light of the rapid pace at which new scientific information is becoming available, the diversity of fields where research evidence is growing rapidly and their potential importance for current policies, UNAIDS is ensuring it has adequate capacity to assess and assimilate the latest scientific developments to inform UNAIDS policies and advance the global AIDS response.