This document provides an overview of the WFP/UNAIDS rapid cash transfer pilot initiative launched in July 2020. The pilot aimed to mitigate the socioeconomic impact of COVID-19 among vulnerable people living with HIV and key populations in four priority countries in western and central Africa. This report complements four country-specific case studies by synthesizing programmatic insights and broader policy implications to support inclusive, HIV-sensitive social protection. In alignment with the Global AIDS Strategy 2021–2026, this report advocates for people-centred, responsive programming that fosters proactive partnership with communities and acknowledges the interdependencies among rights, social protection and health for people who are living with, affected by and at risk of HIV. See related country case studies: Burkina Faso | Cameroon | Côte d'Ivoire | Niger