The annual number of new HIV infections in eastern Europe and central Asia continues to rise. It reached 140 000 [120 000–160 000] in 2023, a 20% increase since 2010 . The region is off track to reach the targets to end AIDS by 2030. Four countries (Kazakhstan, Russian Federation, Ukraine, Uzbekistan) report 92% of all new registered HIV cases in the region according to published case reports from 15 of 16 countries. In 2022, 94% of new HIV infections were among people from key populations and their sex partners, and 15% of new infections were among sex workers. HIV case reporting in the region suggests that an increasing proportion of new HIV infections are transmitted sexually. Available data suggest one explanation for this is transmission from people who inject drugs or formerly injected drugs to their partners in addition to a growing recognition of transmission among men who have sex with men. Unsafe drug injecting practices are a key factor in the region’s epidemic, representing 27% of new HIV infections. Related links: New UNAIDS report shows AIDS pandemic can be ended by 2030, but only if leaders boost resources and protect human rights now | Full report