The 2025 funding crisis has thrown the AIDS response into turmoil with massive disruptions to HIV prevention and community led services, particularly for the most vulnerable. However, the new report by UNAIDS shows evidence that resilience, investment and innovation combined with global solidarity still offer a path to end AIDS. 

GENEVA, 25 November 2025—The global response to HIV has suffered its most significant setback in decades, warns a new UNAIDS report released today ahead of World AIDS Day 2025. Overcoming Disruption, Transforming the AIDS Response details the far-reaching consequences of international funding reductions and lack of global solidarity which sent shockwaves through low- and middle-income countries heavily affected by HIV.

Abrupt reductions in international HIV assistance in 2025 have deepened existing funding shortfalls. The OECD estimates that external health assistance is projected to drop by 30–40% in 2025 compared with 2023, causing immediate and even more severe disruption to health services in low- and middle-income countries.

“The funding crisis has exposed the fragility of the progress we fought so hard to achieve,” said Winnie Byanyima, Executive Director of UNAIDS. “Behind every data point in this report are people—babies and children missed for HIV screening or early HIV diagnosis, young women cut off from prevention support, and communities suddenly left without services and care. We cannot abandon them. We must overcome this disruption and transform the AIDS response.”

A global system in shock

Prevention services—already under strain before the crisis—have been hit hardest. Major reductions in access medicines to prevent HIV (pre-exposure prophylaxis referred to as PrEP) and sharp declines in voluntary medical male circumcision for HIV prevention have left a growing protection gap for millions. The dismantling of HIV prevention programmes designed with and for young women have deprived adolescent girls and young women of HIV prevention, mental health, and gender-based violence services in many countries. This increases their vulnerability further—already in 2024 there were globally 570 new HIV infections every day among young women and girls aged 15—24.

Community-led organizations—the backbone of the HIV response and who were able to reach people most vulnerable to HIV—report widespread closures, with more than 60% of women-led organizations suspending essential programmes. Services for key populations including men who have sex with men, sex workers, people who inject drugs and transgender people have also been severely impacted.

A failure to reach the 2030 global HIV targets of the next Global AIDS Strategy could result in an additional 3.3 million new HIV infections between 2025 and 2030.

Mounting human rights concerns

The funding crisis has unfolded against a deteriorating global human rights environment, with particularly severe consequences for marginalized populations. In 2025, the number of countries criminalizing same-sex sexual activity and gender expression rose for the first time since UNAIDS began monitoring punitive laws in 2008. Restrictions on civil society—particularly those working with key populations globally and young women and girls in sub-Saharan Africa—are further disrupting essential access to HIV services.

Resilience and innovation offer hope

Despite these challenges, several countries have taken swift action in a bid to close funding gaps. As a result, many countries are showing resilience when it comes to HIV treatment delivery. Some countries have reported relatively steady numbers or even an increase in new initiations on antiretroviral therapy as a result of swift action to maintain services.

Nigeria, Uganda, Côte d’Ivoire, South Africa, and Tanzania have all committed to increasing domestic investments in HIV services. UNAIDS is working with more than 30 countries to accelerate national sustainability plans.

Innovation is also gaining momentum. HIV prevention technologies—including twice yearly injections to prevent HIV—have the potential to prevent tens of thousands of new infections in high-burden settings. New partnerships announced in 2025 by the Gates Foundation, UNITAID, the Global Fund to Fight AIDS, TB and Malaria, and the US President’s Emergency Plan for AIDS Relief have launched initiatives to ensure widespread access to affordable generic formulations of life-saving medicines, for as little as USD 40 per person per year in some cases.

“We know what works—we have the science, tools, and proven strategies,” said Ms. Byanyima. “What we need now is political courage. Investing in communities, in prevention, in innovation and in protecting human rights as the path to end AIDS.”

Developments in the latter half of 2025 offer some hope for sustaining critical international financing. The US released its new America First Global Health Strategy and is establishing bilateral agreements with around 70 countries to continue funding during a progressive transfer to self-reliant national HIV responses over the next two to five years. The Global Fund’s recent Eighth Replenishment conference also generated pledges of USD $11.34 billion with more partners still to come forward. This is an extraordinary achievement.

A call to action

Today, 40.8 million people are living with HIV worldwide, 1.3 million new infections occurred in 2024, and 9.2 million people are still not accessing treatment.

This World AIDS Day, UNAIDS is calling on global leaders to:

• Reaffirm global solidarity, multilateralism and the collective commitment to fight and end AIDS together.
  • This is the bedrock of our progress to date. The heath and debt commitments in the Leaders Declaration at the G20 Summit and the Global Fund replenishment last weekend reinforce signs of hope.
• Maintain funding for the response
  • International assistance must be sustained for countries that need it most to ensure a gradual, secure and sustainable transition to domestic financing.
  • Domestic financing cannot grow fast enough to fill the gap, so continued global support is critical.
  • Commitments to urgent and meaningful debt restructuring per the G20 Leaders Declaration are essential to release resources currently tied up in debt repayments.
• Invest in innovation, including affordable long-acting prevention and treatment options.
  • Expand and accelerate the roll out of lenacapavir to move quickly to reach 20 million people
  • License more companies to produce to scale to reduce the costs further
• Uphold human rights. Empower communities.
  • We call on all partners to defend the right to health as a fundamental human right. This means standing firm for bodily autonomy and sexual and reproductive health and rights, ensuring that every person has the freedom and dignity to make decisions about their own body and health.
  • And we must strengthen community-led action, because communities are at the heart of every successful response. Their voices, leadership, and lived experience drive progress and accountability.

After decades of struggle, the global HIV response was within reach of its goal of ending AIDS as a public health threat by 2030. The world has come too far—and achieved too much—to allow progress to unravel at this moment of historic opportunity.

“This is our moment to choose,” Ms. Byanyima urged. “We can allow these shocks to undo decades of hard-won gains, or we can unite behind the shared vision of ending AIDS. Millions of lives depend on the choices we make today.”

UNAIDS

The Joint United Nations Programme on HIV/AIDS (UNAIDS) leads and inspires the world to achieve its shared vision of zero new HIV infections, zero discrimination and zero AIDS-related deaths. UNAIDS unites the efforts of 11 UN organizations—UNHCR, UNICEF, WFP, UNDP, UNFPA, UNODC, UN Women, ILO, UNESCO, WHO and the World Bank—and works closely with global and national partners towards ending the AIDS epidemic by 2030 as part of the Sustainable Development Goals. Learn more at unaids.org and connect with us on Facebook, Twitter, Instagram and YouTube.

JOHANNESBURG/GENEVA, 24 November 2025—UNAIDS welcomes the important pledges from donors for the Global Fund to Fight AIDS, Tuberculosis and Malaria (Global Fund), at its eighth replenishment conference held in Johannesburg, South Africa on 21 November. The event, co-hosted by President Ramaphosa of South Africa and Prime Minister Starmer of the United Kingdom, was held on the margins of the G20 Leaders’ Summit.

Partners around the world pledged US$ 11.34 billion to sustain the fight against AIDS, tuberculosis and malaria which will save millions more lives, and strengthen systems for health. This is a significant achievement and a powerful demonstration of global solidarity in the face of uncertainty and massive disruptions to the HIV response.

“AIDS is not over,” said Winnie Byanyima, UNAIDS Executive Director. “We commend donors for this strong show of support. These pledges will help protect future generations and accelerate progress toward ending these epidemics. But we must go further—our shared goal is US$18 billion, and we look forward to additional pledges to close the gap.”

UNAIDS thanks South Africa and the United Kingdom for hosting this historic Replenishment—the first ever held on the African continent. African countries, themselves, recipients of Global Fund grants, collectively pledged US$ 51.59 million, reaffirming their commitment to financing their own health systems and driving innovation.

The Global Fund’s new approach—embracing agile, country-driven partnerships and mobilizing domestic resources—aligns with UNAIDS’ vision of shared responsibility and sustainability. These investments will not only save lives but also strengthen health systems, bolster economic stability, and advance global health security.

UNAIDS calls on all partners to maintain momentum and ensure resources are swiftly translated into programmes that reach people in need. UNAIDS stands together with the Global Fund. With essential data to guide the Global Fund’s investments, with policy reform at the country level, and with prevention at the centre, we can overcome the disruption to the global HIV response and we can end AIDS.

UNAIDS

The Joint United Nations Programme on HIV/AIDS (UNAIDS) leads and inspires the world to achieve its shared vision of zero new HIV infections, zero discrimination and zero AIDS-related deaths. UNAIDS unites the efforts of 11 UN organizations—UNHCR, UNICEF, WFP, UNDP, UNFPA, UNODC, UN Women, ILO, UNESCO, WHO and the World Bank—and works closely with global and national partners towards ending the AIDS epidemic by 2030 as part of the Sustainable Development Goals. Learn more at unaids.org and connect with us on Facebook, Twitter, Instagram and YouTube.